Impact of Mixed Reality on Middle Cerebral Artery Aneurysm Clipping: Initial Experience With 25 Cases #
Colombo E et al. · Operative neurosurgery (Hagerstown, Md.) · 2026
Neurosurgery · Comparative study · n: 50 cases (25 MxR, 25 control)
Positive finding“In 2 cases (8%), surgical planning with MxR led to the modification of the approach or the head's positioning.”
2 cases (8%)
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A patient-specific, interactive, multiuser, online mixed-reality neurosurgical training and planning system #
Wang J et al. · Neurosurgical focus · 2024
Neurosurgery · Prospective cohort · n: 40 patients
Positive finding“The surgeons changed their exploration strategy in 48.3% of the NVC cases.”
48.3%
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Mixed Reality for Cranial Neurosurgical Planning: A Single-Center Applicability Study With the First 107 Subsequent Holograms #
Colombo E et al. · Operative neurosurgery (Hagerstown, Md.) · 2023
Neurosurgery · Prospective cohort · n: 107 cases
Mixed“Based on the 3D hologram, the surgical approach was modified in 3 cases.”
3 cases
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Immersive 3-Dimensional Virtual Reality Modeling for Case-Specific Presurgical Discussions in Cerebrovascular Neurosurgery #
Sugiyama T et al. · Operative neurosurgery (Hagerstown, Md.) · 2021
Neurosurgery · Prospective cohort · n: 18 patients
Positive finding“The VR session also effectively improved the decision-making process regarding minor surgical techniques in 61.1% of cases”
61.1%
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Cerebral Anatomy Detection and Surgical Planning in Patients with Anterior Skull Base Meningiomas Using a Virtual Reality Technique #
Zawy Alsofy S et al. · Journal of clinical medicine · 2021
Neurosurgery · Retrospective cohort · n: 30 patients
Positive finding“The 3D-VR modality significantly influenced the detection of tumor-related anatomical structures (p = 0.002), recommended head positioning (p = 0.005), and surgical approach (p = 0.03).”
p = 0.005
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Evaluation of Surgical Approaches for Tumor Resection in the Deep Infratentorial Region and Impact of Virtual Reality Technique for the Surgical Planning and Strategy #
Zawy Alsofy S et al. · The Journal of craniofacial surgery · 2020
Neurosurgery · Retrospective cohort · n: 93 patients
Mixed“Image presentation using VR had a significant influence on the recommended surgical approach (P = 0.02), but no influence on the recommended patient positioning (P = 0.37) or placement of craniotomy (P = 0.09).”
P = 0.02
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Impact of Virtual Reality in Arterial Anatomy Detection and Surgical Planning in Patients with Unruptured Anterior Communicating Artery Aneurysms #
Zawy Alsofy S et al. · Brain sciences · 2020
Neurosurgery · Retrospective cohort · n: 26 patients
Positive finding“The 3D-VR modality significantly influenced detection of the aneurysm-related vascular structure (p = 0.0001), the recommended head positioning (p = 0.005), and the surgical approach (p = 0.001) in the planning of microsurgical clipping.”
p = 0.001
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Anatomic Review in 3D Augmented Reality Alters Craniotomy Planning Among Residents #
Haider S et al. · World neurosurgery · 2024
Neurosurgery · Survey/user study · n: 6 cases
Mixed“Skull position significantly changed in 5 out of 6 cases after 3D-AR view (P < 0.05, 20° angular adjustment).”
5 out of 6 cases
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The role of extended reality in eloquent area lesions: a systematic review #
Marrone S et al. · Neurosurgical focus · 2024
Neurosurgery · Systematic review
Positive finding“The increasing use of such innovative technologies has completely changed the way to approach a lesion, using 3D visualization to foster a better understanding of its anatomical and vascular characteristics.”
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Application of virtual and mixed reality for 3D visualization in intracranial aneurysm surgery planning: a systematic review #
Colombo E et al. · Frontiers in surgery · 2023
Neurosurgery · Systematic review
Positive finding“A positive impact on surgical planning was documented by 19 studies (67.9%)…”
67.9%
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Virtual Reality in Neurosurgery: "Can You See It?"-A Review of the Current Applications and Future Potential #
Fiani B et al. · World neurosurgery · 2020
Neurosurgery · Narrative review
Positive finding“In cranial surgery, VR has excelled in helping neurosurgeons design unique patient-specific approaches to particularly challenging tumor excisions.”
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Iterative Virtual and Physical Simulation for Staged Separation of Total Vertical Craniopagus: The Avatar Patient Approach to Conjoined Twins #
Giussani CG et al. · Operative neurosurgery (Hagerstown, Md.) · 2026
Neurosurgery · Experience report · n: 1 patient (twin pair)
Positive finding“The integrated simulation reshaped the multistep approach, allowing venous partition strategies and refined cranial reconstruction planning to be discussed, replicated, and enhanced multidisciplinarily.”
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Augmented reality in cranial surgery: Surgical planning and maximal safety in resection of brain tumors via head-mounted fiber tractography #
Gurses ME et al. · Clinical neurology and neurosurgery · 2025
Neurosurgery · Case report · n: 1 patient
Positive finding“This technological setup was employed for pre-operative and intraoperative planning and further enhanced clinical decision-making for the actual tumor resection.”
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Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery #
Shields LBE et al. · Epilepsia open · 2025
Neurosurgery · Experience report · n: 85 patients
Positive finding“The multi-layered and 3D model of the ST system facilitates epilepsy decision-making for both diagnosis and treatment, enhances surgical navigation, and even allows, in a robust virtual reality (VR) environment, the practice of complex surgical procedures.”
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Case Report: Use of novel AR registration system for presurgical planning during vestibular schwannoma resection surgery #
Olexa J et al. · Frontiers in surgery · 2024
Neurosurgery · Case report · n: 1 patient
Positive finding“This allowed the surgeon to plan the craniotomy location and optimize proper head position.”
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Exploring the Potential Use of Virtual Reality with a Supraorbital Keyhole Craniotomy for Anterior Skull Base Meningiomas: Two Case Reports #
Valerio J et al. · Journal of personalized medicine · 2024
Neurosurgery · Case series · n: 2 patients
Positive finding“We can utilize VR/AR technologies to identify patients that will benefit from an SOKC and expand the implementation of the approach beyond its current limitations.”
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Case report: Impact of mixed reality on anatomical understanding and surgical planning in a complex fourth ventricular tumor extending to the lamina quadrigemina #
Colombo E et al. · Frontiers in surgery · 2023
Neurosurgery · Case report · n: 1 patient
Positive finding“The application of advanced 3D visualization with a novel MxR system to the surgical planning of a complex fourth ventricular lesion proved relevant in designing the best surgical approach and trajectory to better identify potential intraoperative challenges and rehearse the patient-specific anatomy.”
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The "Canopy Approach": Case Series Using Immersive Virtual Reality for Bottom-Up Target-Based Preoperative Planning in Pediatric Neurosurgery #
Lai GY et al. · Neurosurgery practice · 2023
Neurosurgery · Case series · n: 5 patients
Positive finding“Modifications to 2-dimensional and "top-down" VR trajectory plans were made after "bottom-up" navigation in all cases.”
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Extended reality platform for minimally invasive endoscopic evacuation of deep-seated intracerebral hemorrhage: illustrative case #
Steineke TC, Barbery D · Journal of neurosurgery. Case lessons · 2022
Neurosurgery · Case report · n: 1 patient
Positive finding“We then revised the approach using the 360VR model, allowing us to fly through the plan and ensure that no vital structures were compromised”
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Patient-specific virtual reality technology for complex neurosurgical cases: illustrative cases #
Anthony D et al. · Journal of neurosurgery. Case lessons · 2021
Neurosurgery · Case series · n: 5 patients
Positive finding“For two cases, the plan changed after reviewing the patient's 360°VR model from one based on conventional Digital Imaging and Communications in Medicine imaging.”
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SURG-03. IMMERSIVE VIRTUAL REALITY APPLICATIONS IN NEUROSURGICAL ONCOLOGY #
Carai A et al. · Neuro-Oncology · 2020
Neurosurgery · Conference abstract · n: 60 patients
Positive finding“Use of the 3D VR was used during preoperative planning allowing a better definition of surgical strategy.”
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