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Research Library · Independent literature review

Neurosurgery: Does VR surgical planning improve patient outcomes?

20 Neurosurgery studies in the library address this question.

Neurosurgery: Patient outcomesBar chart. Neurosurgery: Patient outcomes. Comparative or prospective studies 1, Retrospective studies 7, Reviews 2, Case reports & technical 10.RESEARCH LIBRARY · INDEPENDENT LITERATURE REVIEWNeurosurgery: Patient outcomes20 studies in the library, by study designComparative or prospecti…1Retrospective studies7Reviews2Case reports & technical10Positive findingMixedDescriptiveNo significant differenceRealize Medical Research Library · 631 studies · updated 2026-10-03

What the studies report

  • Positive finding
    “Clinically, group A demonstrated significant advantages with shorter operative duration, reduced intraoperative blood loss, higher rate of gross-total resection, lower complication incidence, and better postoperative mRS scores (all p < 0.05).”

    Hou 2025 · Prospective cohort · n: 130 patients

  • Positive finding
    “VR-based surgical planning was associated with significantly smaller craniotomy sizes and shorter hospital stays.”

    Greuter 2025 · Retrospective cohort · n: 159 patients

  • Positive finding
    “Surgeons involved in separating craniopagus twins have increasingly utilized tools such as CAD/CAM models, VSP and AR/VR to plan and execute successful separation, and these tools are associated with higher success rates than historical controls.”

    Pontell 2024 · Narrative review

  • Positive finding
    “The majority (82%) included cranial based applications related to tumor surgery with 34% showing improved resection rates and functional outcomes.”

    Dadario 2021 · Systematic review

How strong is the evidence?

Of 20 studies with a finding on this question: 4 report a positive finding, 16 descriptive. These reflect what each study's authors report.

Study designs: 1 comparative or prospective study, 7 retrospective studies, 2 reviews and 10 case reports, case series and technical reports.

All 20 studies

Open-source AI-assisted rapid 3D color multimodal image fusion and preoperative augmented reality planning of extracerebral tumors #

Hou X et al. · Neurosurgical focus · 2025

Neurosurgery · Prospective cohort · n: 130 patients

Positive finding
“Clinically, group A demonstrated significant advantages with shorter operative duration, reduced intraoperative blood loss, higher rate of gross-total resection, lower complication incidence, and better postoperative mRS scores (all p < 0.05).”

p < 0.05

DOIPubMed

Role of mixed reality in the workflow of complex neurooncological surgeries: a case analysis in thalamic surgery #

Zanuttini L et al. · Acta neurochirurgica · 2025

Neurosurgery · Retrospective case series · n: 9 patients (10 procedures)

Descriptive
“The mean extent of resection achieved was 94.88% (range: 78.6%-100%).”

94.88%

DOIPubMedFree full text

Minimally invasive approaches using virtual reality planning in elective aneurysm surgery #

Greuter L et al. · Frontiers in surgery · 2025

Neurosurgery · Retrospective cohort · n: 159 patients

Positive finding
“VR-based surgical planning was associated with significantly smaller craniotomy sizes and shorter hospital stays.”

DOIPubMedFree full text

Virtual Reality Planning of Microvascular Decompression in Trigeminal Neuralgia: Technique and Clinical Outcome #

Fabrig OD et al. · Journal of neurological surgery. Part A, Central European neurosurgery · 2024

Neurosurgery · Retrospective case series · n: 26 patients

Descriptive
“The surgical complication rate was zero.”

DOIPubMed

Three-Dimensional Virtual Reality Simulation to Safe Planning Neurosurgical Procedure in Brain Aneurysms, Latin American Single-Center Experience: Advantages and Limitations #

Zárate-Méndez AM et al. · Indian Journal of Neurosurgery · 2021

Neurosurgery · Retrospective case series · n: 34 patients

Descriptive
“There were no intraoperative complications in any patient.”

DOI

Three-Dimensional Modeling of Complex Pediatric Intracranial Aneurysmal Malformations With a Virtual Reality System #

Yan EG et al. · Simulation in healthcare · 2021

Neurosurgery · Retrospective case series · n: 5 patients

Descriptive
“There were no perioperative complications for patients treated with open surgery.”

DOIPubMed

Evaluation of Surgical Approaches for Tumor Resection in the Deep Infratentorial Region and Impact of Virtual Reality Technique for the Surgical Planning and Strategy #

Zawy Alsofy S et al. · The Journal of craniofacial surgery · 2020

Neurosurgery · Retrospective cohort · n: 93 patients

Descriptive
“Surgical tumor resections were associated with an overall complication rate comparable to the literature.”

DOIPubMed

[Application of diffusion tensor imaging combined with virtual reality three-dimensional reconstruction in the operation of gliomas involved eloquent regions] #

Chen SH et al. · Beijing da xue xue bao. Yi xue ban · 2019

Neurosurgery · Retrospective case series · n: 35 patients

Descriptive
“Complete resection of enhancing tumor (CRET) was achieved in 30 cases (85.7%), subtotal resection in 5 cases (14.3%), neurological function improved in 34 cases (97.1%) after operation,and 1 case had no improvement compared with that before(2.9%).”

85.7%

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Putting our heads together: The future of craniopagus twin separation #

Pontell ME et al. · Journal of cranio-maxillo-facial surgery · 2024

Neurosurgery · Narrative review

Positive finding
“Surgeons involved in separating craniopagus twins have increasingly utilized tools such as CAD/CAM models, VSP and AR/VR to plan and execute successful separation, and these tools are associated with higher success rates than historical controls.”

DOIPubMed

Examining the benefits of extended reality in neurosurgery: A systematic review #

Dadario NB et al. · Journal of clinical neuroscience · 2021

Neurosurgery · Systematic review

Positive finding
“The majority (82%) included cranial based applications related to tumor surgery with 34% showing improved resection rates and functional outcomes.”

34%

DOIPubMed

Circumferential venous sinus: an innovative separation method for total vertical type II craniopagus twins #

Mufarrej G et al. · Journal of neurosurgery. Pediatrics · 2026

Neurosurgery · Case report · n: 1 patient (twin pair)

Descriptive
“The final separation, completed in 2 stages over 31 hours, resulted in successful independent circulations and recovery.”

DOIPubMed

Virtual Planning and Augmented Reality-Guided Microsurgical Resection of a Frontal Arteriovenous Malformation #

Halpin BS et al. · World neurosurgery · 2024

Neurosurgery · Case report (video) · n: 1 patient

Descriptive
“The patient was discharged home on postoperative day 3 with no complications.”

DOIPubMed

How I do it: preoperative simulation and augmented reality assisted surgical resection of Glioblastoma in Broca's area #

Guo J et al. · Acta neurochirurgica · 2024

Neurosurgery · Case report · n: 1 patient

Descriptive
“Gross total resection and favorable functional outcome were finally achieved.”

DOIPubMedFree full text

Case report: Impact of mixed reality on anatomical understanding and surgical planning in a complex fourth ventricular tumor extending to the lamina quadrigemina #

Colombo E et al. · Frontiers in surgery · 2023

Neurosurgery · Case report · n: 1 patient

Descriptive
“Through the combined use of routine 2D images and an interactive 3D anatomical model, an interhemispheric transtentorial approach was used to remove 98% of the lesion with successful functional outcomes.”

98%

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How I do it? Preoperative Microsoft HoloLens 2 planning-assisted surgical clipping of a fetal posterior cerebral artery aneurysm #

Yan X et al. · Acta neurochirurgica · 2023

Neurosurgery · Case report · n: 1 patient

Descriptive
“The patient was cured without any complications.”

DOIPubMed

The "Canopy Approach": Case Series Using Immersive Virtual Reality for Bottom-Up Target-Based Preoperative Planning in Pediatric Neurosurgery #

Lai GY et al. · Neurosurgery practice · 2023

Neurosurgery · Case series · n: 5 patients

Descriptive
“There were no complications, and no patients suffered permanent neurological deficits postoperatively.”

DOIPubMedFree full text

Early Experience With Virtual and Synchronized Augmented Reality Platform for Preoperative Planning and Intraoperative Navigation: A Case Series #

Louis RG et al. · Operative neurosurgery (Hagerstown, Md.) · 2021

Neurosurgery · Case series · n: 49 patients

Descriptive
“All aneurysm clipping and microvascular decompression procedures were completed without complications.”

DOIPubMedFree full text

A Virtual-Reality, 360-Degree Fly-Through of an Arteriovenous Malformation Resection: 2-Dimensional Operative Video #

Steinberger J et al. · Operative neurosurgery (Hagerstown, Md.) · 2020

Neurosurgery · Case report (video) · n: 1 patient

Descriptive
“The AVM was safely resected using navigation integrated with VR; careful arterial devascularization preceded resection of the draining veins and then the AVM nidus.”

DOIPubMed

Virtual Reality Surgical Rehearsal and 2-Dimensional Operative Video of a Paramedian Supracerebellar Infratentorial Approach Endoscopic Resection of Pineocytoma: 2-Dimensional Operative Video #

Jean WC · Operative neurosurgery (Hagerstown, Md.) · 2020

Neurosurgery · Case report (video) · n: 1 patient

Descriptive
“Given the rarity of pineocytoma,5 the novelty of endoscopic resection of solid tumors in the region, and the challenge of "keyhole" approaches to deep-lying targets, VR rehearsal facilitated the achievement of the surgical goal and avoided the morbidity of a more extensive exposure.”

DOIPubMed

Optimization of skull base exposure using navigation-integrated, virtual reality templates #

Jean WC et al. · Journal of clinical neuroscience · 2020

Neurosurgery · Case series · n: 2 patients

Descriptive
“Complete resections were achieved and neither patient suffered any approach-related complications.”

DOIPubMed

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Summarises published research on VR/AR surgical planning across all platforms. Not product labelling. For Elucis indications see /elucis.

Intended for healthcare professionals.

Summaries and quotes describe each study's methods and the findings its authors report. They are not claims by Realize Medical and may contain errors: please read the original paper. Inclusion is not an endorsement of any product or use.