Realize Medical
Research Library · Independent literature review

Neurosurgery: What is the evidence for HoloLens in surgical planning?

20 Neurosurgery studies in the library address this question.

Neurosurgery: HoloLensBar chart. Neurosurgery: HoloLens. Comparative or prospective studies 5, Retrospective studies 1, Surveys and user studies 1, Case reports & technical 13.RESEARCH LIBRARY · INDEPENDENT LITERATURE REVIEWNeurosurgery: HoloLens20 studies in the library, by study designComparative or prospecti…5Retrospective studies1Surveys and user studies1Case reports & technical13StudiesRealize Medical Research Library · 631 studies · updated 2026-10-03

What the studies report

  • “In 2 cases (8%), surgical planning with MxR led to the modification of the approach or the head's positioning.”

    Colombo 2026 · Comparative study · n: 50 cases (25 MxR, 25 control)

  • “The percentage deviation between both groups was 5.9%, indicating high transferability of preoperative planning.”

    Lehmann 2026 · Validation study · n: 83 patients

  • “The surgeons changed their exploration strategy in 48.3% of the NVC cases.”

    Wang 2024 · Prospective cohort · n: 40 patients

  • “During phantom testing, registration errors remained below 2.0 mm and 2.0° for both AR-based navigation and conventional neuronavigation, with no significant difference between both systems.”

    Van Gestel 2023 · Prospective cohort · n: 20 patients

How strong is the evidence?

Study designs: 5 comparative or prospective studies, 1 retrospective study, 1 survey or user study and 13 case reports, case series and technical reports.

All 20 studies

Impact of Mixed Reality on Middle Cerebral Artery Aneurysm Clipping: Initial Experience With 25 Cases #

Colombo E et al. · Operative neurosurgery (Hagerstown, Md.) · 2026

Neurosurgery · Comparative study · n: 50 cases (25 MxR, 25 control)

“In 2 cases (8%), surgical planning with MxR led to the modification of the approach or the head's positioning.”

2 cases (8%)

DOIPubMedFree full text

From planning to execution: Interactive virtual-reality assisted craniotomy planning in meningioma surgery #

Lehmann S et al. · Brain & spine · 2026

Neurosurgery · Validation study · n: 83 patients

“The percentage deviation between both groups was 5.9%, indicating high transferability of preoperative planning.”

5.9%

DOIPubMedFree full text

A patient-specific, interactive, multiuser, online mixed-reality neurosurgical training and planning system #

Wang J et al. · Neurosurgical focus · 2024

Neurosurgery · Prospective cohort · n: 40 patients

“The surgeons changed their exploration strategy in 48.3% of the NVC cases.”

48.3%

DOIPubMedFree full text

Neuro-oncological augmented reality planning for intracranial tumor resection #

Van Gestel F et al. · Frontiers in neurology · 2023

Neurosurgery · Prospective cohort · n: 20 patients

“During phantom testing, registration errors remained below 2.0 mm and 2.0° for both AR-based navigation and conventional neuronavigation, with no significant difference between both systems.”

DOIPubMedFree full text

Mixed Reality for Cranial Neurosurgical Planning: A Single-Center Applicability Study With the First 107 Subsequent Holograms #

Colombo E et al. · Operative neurosurgery (Hagerstown, Md.) · 2023

Neurosurgery · Prospective cohort · n: 107 cases

“Based on the 3D hologram, the surgical approach was modified in 3 cases.”

3 cases

DOIPubMedFree full text

Role of mixed reality in the workflow of complex neurooncological surgeries: a case analysis in thalamic surgery #

Zanuttini L et al. · Acta neurochirurgica · 2025

Neurosurgery · Retrospective case series · n: 9 patients (10 procedures)

“The additional planning time for segmentation averaged 45 min.”

45 min

DOIPubMedFree full text

Augmented reality for epilepsy surgery: Examining usability and efficacy in presurgical planning #

Chilappa R et al. · Epileptic disorders · 2025

Neurosurgery · Survey/user study · n: 5 patient datasets

“Survey results from 18 faculty members regarding seven questions indicated that AREP was user-friendly and can be effective in presurgical planning moving forward.”

DOIPubMedFree full text

An Augmented Reality-Based Navigation System for Stereotactic Brain Biopsy with Multi-Objective Path Planning and Hybrid Registration #

Zhang T et al. · Brain sciences · 2026

Neurosurgery · Technical development

“An expert study across four common brain tumor locations demonstrated that the MOO model significantly outperformed manual methods in satisfying safety criteria.”

DOIPubMedFree full text

Augmented reality and 3D modeling for preoperative planning in microsurgical resection of brain arteriovenous malformations: A proof-of-concept study #

Konovalov A et al. · Surgical neurology international · 2025

Neurosurgery · Case series · n: 20 patients

“Preoperative modeling required 15.3 ± 5.1 min, while AR navigation averaged 12.7 ± 3.2 min.”

15.3 ± 5.1 min

DOIPubMedFree full text

Case Report: Use of novel AR registration system for presurgical planning during vestibular schwannoma resection surgery #

Olexa J et al. · Frontiers in surgery · 2024

Neurosurgery · Case report · n: 1 patient

“This technology allows for efficient and accurate registration of a patient's 3D anatomical model onto their head while positioned in the operating room.”

DOIPubMedFree full text

How I do it: preoperative simulation and augmented reality assisted surgical resection of Glioblastoma in Broca's area #

Guo J et al. · Acta neurochirurgica · 2024

Neurosurgery · Case report · n: 1 patient

“Gross total resection and favorable functional outcome were finally achieved.”

DOIPubMedFree full text

Development of a mixed reality application to simulate neurosurgical procedures #

Hari K et al. · Medical Imaging · 2023

Neurosurgery · Technical development

“Initial responses indicated that the prototype could be an effective surgical teaching and planning tool for less-experienced neurosurgeons because it could allow neurosurgeons to view physical and image space simultaneously.”

DOI

The use of mixed reality for the treatment planning of unruptured intracranial aneurysms #

Stifano V et al. · Journal of neurosurgical sciences · 2023

Neurosurgery · Case series · n: 5 patients

“The graphic performance was also deemed very satisfactory.”

DOIPubMed

How I do it? Preoperative Microsoft HoloLens 2 planning-assisted surgical clipping of a fetal posterior cerebral artery aneurysm #

Yan X et al. · Acta neurochirurgica · 2023

Neurosurgery · Case report · n: 1 patient

“During the operation, we successfully identified the planned relationship between the aneurysm and the fetal PCA.”

DOIPubMed

Magnetic resonance imaging based neurosurgical planning on hololens 2: A feasibility study in a paediatric hospital #

Antonelli M et al. · Digital health · 2023

Neurosurgery · Feasibility study · n: 1 patient

“We have successfully created a valuable and easy-to-use neuroimaging data mixed reality app, laying the foundation for more future clinical uses, as more models and data derived from various biomedical images can be imported.”

DOIPubMedFree full text

Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning #

Noecker AM et al. · Brain stimulation · 2023

Neurosurgery · Technical development

DOIPubMedFree full text

A Holographic Augmented Reality Interface for Visualizing of MRI Data and Planning of Neurosurgical Procedures #

Morales Mojica CM et al. · Journal of digital imaging · 2021

Neurosurgery · Technical development

“A preliminary qualitative evaluation revealed that holographic visualization of high-resolution 3D MRI data offers an intuitive and interactive perspective of the complex brain vasculature and anatomical structures.”

DOIPubMedFree full text

Augmented reality head-mounted display-based incision planning in cranial neurosurgery: a prospective pilot study #

Ivan ME et al. · Neurosurgical focus · 2021

Neurosurgery · Feasibility study · n: 11 patients

“Five patient procedures were rated as having an excellent correspondence degree, 5 had an adequate correspondence degree, and 1 had poor correspondence.”

DOIPubMedFree full text

3D Holographic Visualization for Pre-procedural Planning of Spatially Complex Brain Aneurysm Treatment #

Weunski CJ et al. · Research Square · 2020

Neurosurgery · Preprint (technical development) · n: 1 patient

“Feedback from testing the prototype indicated potential for augmented reality to assist an interventionalist in spatial understanding and depth perception of spatially complex anatomy and could increase confidence in pre-procedural planning.”

DOI

Clinical Feasibility of a Wearable Mixed-Reality Device in Neurosurgery #

Incekara F et al. · World neurosurgery · 2018

Neurosurgery · Feasibility study · n: 25 patients

“Holograms were successfully created in all cases.”

DOIPubMed

All neurosurgery studiesThis question across specialtiesBrowse the whole library

Summarises published research on VR/AR surgical planning across all platforms. Not product labelling. For Elucis indications see /elucis.

Intended for healthcare professionals.

Summaries and quotes describe each study's methods and the findings its authors report. They are not claims by Realize Medical and may contain errors: please read the original paper. Inclusion is not an endorsement of any product or use.